Hetz Lab Laboratory of cellular stress and biomedicine
Faculty of Medicine University of Chile
Hetz lab Home Research Contact Publications
PUBLICATIONS, REVIEWS AND BOOK CHAPTERS

*Publications with affiliation to the University of Chile
#Corresponding author

 

1

Hetz C. and Glimcher L. (2008). The UPRosome and XBP-1: mastering secretory cell function.  Curr.  Immunol. Rev. 4:1-10 *# PDF
2

Hetz C, Lee AH, Gonzalez-Romero D., Thielen P., Castilla J., Soto C. and Glimcher L. (2008). The   Unfolded Protein Response transcription factor XBP-1 does not influence Prion replication or pathogenesis. Proc. Natl. Acad Sci. 105: 757–762.*#. PDF
3 Hetz C. and Glimcher L. (2008) The deadly job of night Killer: New regulatory roles of the BCL-2 family in organelle physiology. Trends in Cell Biol. 18: 38-44 *# PDF
4 Hetz C. (2008). Apoptosis, Autophagy and Necrosis: From mechanisms to biomedical applications. Curr. Mol. Med. Editorial comment as executive editor special edition. In press PDF
5 Matus S., Lisbona F. Torres M., Leon C., and Hetz C. (2008). The stress rheostat in neurodegeneration: interplay between the Unfolded Protein Response (UPR) and Autophagy. Curr. Mol. Med. In press *# PDF
6 Steele A., Hetz C., Yi C., Jackson W., Borkowski A., Yuan J., Wollmann R., and Lindquist S. (2007). Prion pathogenesis is independent of Caspase-12. Prion. 4:1-5. * PDF
7 Steele A., King O., Jackson W., Hetz C., Borkowski A., Thielen P., Wollmann R., and Lindquist S. (2007). Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo (2007) J. of Neuroscience. 27: 13022-7. * PDF
8 Hetz C. (2007). ER stress signaling: Form adaptation to irreversible cellular damage. Antiox Redox Signal. In press. *# PDF
9 Hetz C.Thielen P., Fisher J., Pacinelli, P., Brown, R., Korsmeyer S. and Glimcher L. (2007). The Pro-apoptotic BCL-2 Family Member BIM Mediates Motoneuron Loss in a Model of Amyotrophic Lateral Sclerosis. Cell Death and Diff. 14(7):1386-1389.*# PDF
10

Hetz, C., Castilla, J. and Soto C. (2007). Perturbation of endoplasmic reticulum homeostasis facilitates prion replication. J. Biol. Chem. 282:12725-33. *# PDF
11 Hetz, C, Bernasconi, P., Fisher, J., Lee, A., Bassik, M., Antonsson, B., Brandt, G., Iwakoshi, N,. Schinzel, A., Glimcher, L. and Korsmeyer, S.  (2006). Proapoptotic BAX and BAK modulate the unfolded protein response by a direct  interaction with IRE1alpha. Science.312: 572-6. # PDF
 

Commented in Nat. Rev. Cell Biol. (2006) 7:388 Handling the stress; ACS Chem. Biol. (2006) 1:188. Stressed out cells.
12 Hetz, C. and Soto, C. 2006. Emerging roles of the Unfolded protein response signaling in physiology and disease. Curr. Mol. Med. 6: 1-3. Editorial comment as executive editor special edition.*# PDF
13 Hetz, C. and Soto, C. 2006. Stressing out the ER: A Role of unfolded protein response in prion-related disorders Curr. Mol. Med. 6:37-43.Review.*# PDF
14 Hetz, C., Vitte, P., Bombrun, A., Rostovtseva, T., Montessuit, S., Hiver, A., Schwarz, M., Church, D., Korsmeyer, S., Martinou, J.C. and Antonsson, B. 2005. Bax channel inhibitors prevent cytochrome c release from mitochondria and protect neurons in a model of global brain ischemia. J. Biol. Chem. 280: 42960-42970.* PDF
15

Hetz, C., Torres, V., and Quest A. 2005. Beyond apoptosis: Non-apoptotic cell death in physiology and disease. Biochem. Cell. Biol. 83:579-588. Review.* PDF
16 Schinzel, A., Takeuchi, O., Huang, Z., Fisher, J., Zhou, Z., Rubens J., Hetz, C. Danial, N., Moskowits, M., and Korsmeyer, S. 2005. Cyclophilin D is an essential component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc. Natl Acad. Sci. U.S.A. 102:12005-12010. PDF
17

Castilla, J., Saa, P., Hetz, C. and Soto, C. 2005. In vitro generation of infectious scrapie prions. Cell. 121:195-206.* PDF
 

Commented in Cell (2005) 121:155-162. From microbes to prions: The final proof of the prion  hypothesis; Science (2005) 421:3. Proof positive for prions; Nature (2005) 432:39. Prion progress; Nature Med. (2005) 11:480. Nothing but prion.
18

Hetz C., Russelakis, M., Wälchli S., Carboni S., Vial-Knecht E., Maundrell K. and Soto, C. 2005. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J. Neurosci. 25:2793-2802.* PDF
19

Russelakis, M., Hetz C., Maundrell K., and Soto, C. 2004. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Am. J. Pathol. 165:1839-1848.* PDF
20

Castilla C., Hetz C., Soto C. 2004. Molecular mechanisms of neurotoxicity of pathological Prion protein. Curr. Mol. Med. 4:397-403. Review.* PDF
21

Hetz C., Russelakis, M., Maundrell, K. Castilla, J. and Soto, C. 2003. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 22:5435-5445. * PDF
 

Commented in Science, STKE (2003) 302:1007. Prions stress out the ER.
22

Hetz, C., Maundrell, K. and Soto, C. 2003. Is loss of function of the prion protein the cause of Prion Disorders? Trends Mol. Med.  9:237-243. Review.* PDF
23

Hetz, C. and Soto, C. 2003. Prion Misfolding and Disease: The Case of Prion Protein. Cell. Mol. Life Sci. 60:133-1432. Review.* PDF
24

Hetz C., Benavent, S. Bieler, S. and Soto, C. 2003. Prion Protein Misfolding and Brain Degeneration. Curr. Med. Chem. 3:137-147. Review.*
25

Hetz, C., Hunn, M., Rojas, P. Leyton, L., and Quest, A. F. 2002. Caspase-dependent Initiation of Apoptosis and Necrosis by the Fas Recetor: A Role for the Lipid Second Messenger Ceramide in Initiation of FasL-induced Necrosis.  J. Cell Sci. 115: 4671-83.* PDF
 

Commented in J. Cell. Sci. (2002) 115:e2304. Apoptosis vs necrosis: ceramide decides it. and in Science, STKE (2002), Issue 158: 414. A Back-up death plan.
26

Hetz, C. Bono, M., Barros, F. and Lagos, R.. 2002. Microcin E492, a Channel-forming Bacteriocin from Klebsiella pneumoniae, Induces Apoptosis in Some Human Cell Lines. Proc. Natl. Acad. Sci USA. 99:2696-2701. * PDF
27

Leyton, L., Schneider, P., Labra, C., Ruegg, C., Hetz, C., Quest, A. and Brown C. 2001. Thy-1 binds to the integrin b3 on astrocytes and triggers formation of focal contact sites. Curr. Biol.11:1028-38.*

28

Barros, F., Stutzin, A., Calixto, A., Catalán, M., Castro, J., Hetz, C., and Hermosilla, T. 2001. Non-selective Cation Channels as Effectors of Free Radical-induced Liver Cell Necrosis.  Hepatology. 33:114-22.*
29

Lagos, R., Baeza, M., Corsini, G., Hetz, C., Strahsburger, E., Castillo J., Vergara C., and Monasterio O. 2001. Structure, Organization and Characterization of the Gene Cluster Involved in the Production of Microcin E492, a Channel-Forming Bacteriocin. Mol. Microbiol. 42: 229-244.*
   
  Book chapters
30

Russelakis-Carneiro, M., Hetz, C., Castilla, J. and Soto, C. (2004) Neurodegeneration induced by prion protein misfolding. In “Neuroprotection: Models, Mechanisms, Therapies” M. Bahr (Ed.). Wiley-VCH.* PDF
31

Morales R., Hetz C. and Soto C. (2004). Signaling Pathways Controlling Prion Neurotoxicity: Role of Endoplasmic reticulum stress-mediated Apoptosis. Neurodegeneration in Prion Disorders.  Klewer. Editor: David Brown. * PDF
33 Matus S., Thielen P., Nassif M., Torres M., and Hetz C (2008) Targeting stress pathways to treat neurological disorders linked to protein misfolding. Protein Misfolding. Nova Science Publishers, Inc.*# PDF