Laboratory of Cellular Stress and Biomedicine
Program of Cellular and Molecular Biology
Institute of Biomedical Sciences
Faculty of Medicine
University of Chile
1027 Independencia. POBox 70086
Santiago, Chile
Phone: Office 56-2-9786506 (Chile); lab 56-2-9786411; FAX: 56-2-9786871 (Chile)
Phone: 1-617-432-0622 (USA), 1-617-4320084 (USA)
chetz@hsph.harvard.edu and chetz@med.uchile.cl
and associate members of The FONDAP Center for Cellular Studies of the Cell, same address.

Collaborators and useful links, founding.

RESEARCH SUPPORT

NAME: Chilean government funding agency FONDECYT.  TITLE: Regulation of the Unfolded Protein Response (UPR) by the stress sensor IRE1α and its role in neurological disorders. ROLE: Principal investigator and project manager. SOURCE and ID: FONDECYT # 1070444 2007-2010.

NAME: High Q Foundation, discovery initiative TITLE: A role of Endoplasmic Reticulum Stress in Huntington’s Disease. ROLE: Pincipal Investigator and project manager  2007-2008.

NAME: The Michael J. Fox Foundation for Parkinson's Research TITLE: A role of the UPR in Parkinson's disease ROLE: Principal Investigator and project manager 2008-2009

NAME: CONAMA TITLE: Análisis de toxicología de los contaminantes del MP 10 Y 2.5”. ROLE: Co-investigator, PI: Pedro Loyola (Centro Mario Molina) SOURE and ID CONAMA - BIP 30067379-0 2007-2008

NAME: Damon Runyon Cancer Research Foundation TITLE: BCL-2 regulation of the endoplasmic reticulum stress response and apoptosis. ROLE: Principal investigator 2004-2007

NAME: National Parkinson Foundation TITLE: Defining the contribution of endoplasmic reticulum (ER) stress in Parkinson's disease. ROLE: Principal investigator and project manager. SOURCE: National Parkinson Foundation, USA 2008-2009.

NAME: Genzyme SA, Sponsor Research Agreement, Boston, USA. TITLE: Gene therapy in neurodegenerative conditions ROLE: Principal investigator and project manager. SOURCE: SRA Genzyme 2008-2010.

NAME: Muscular Dystrophy Association, USA. TITLE: Targeting Autophagy for the removal of mutant SOD1 in ALS. ROLE: Principal Investigator and project manager.   2008-2010.

NAME: CHDI and HighQ Foundation, Research grant, USA. TITLE: Defining the role of the Unfolded Protein Response in Huntington's disease in vivo. ROLE:Principal Investigator and project manager.    2008-2010.

NAME: ICGEB, International Center for Genetic Engineering and Biotechnology, Italy. TITLE: Role of the Unfolded Protein Response (UPR) in tumor suppression by caveolin-1. ROLE: Principal Investigator and project manager.   2008-2011.

 

COLLABORATORS AND USEFUL LINKS, FUNDING
We deeply thank Nina Dudnik and “Seeding labs” (Boston, USA) for providing us with many valuable equipments and materials as donations to our laboratory.
www.seedinglabs.org
1. Claudio Soto, University of Texas Medical Branch, Galveston, USA
http://www.utmb.edu/neuro/faculty_profiles/ClaudioSoto.htm
2. Laurie Glimcher, Harvard School of Public Health,  Boston, USA.
http://www.hsph.harvard.edu/faculty/laurie-glimcher/
3. Jean Claude Martinon, University of Geneva, Geneva, Switzerland
4. Guido Kroemer, Institut Gustave Roussy, Paris, France
5. John Reed, Burnham Institute for Medical Research, La Jolla, USA
http://www.burnham.org/default.asp?contentID=215
6. FONDAP Center for Cellular studies of the Cell, University of Chile, Santiago, Chile.
http://www.cmcmed.cl/eng.htm
The central research theme of this Center is the study of signal transduction mechanisms operating in normal or aberrant cells. The problems addressed in the Center are relevant to understand nerve cell function, hormone action, muscle physiology, cellular death mechanisms and cancer. The specific research areas include studies of signal transduction mechanisms involved in Calcium Signaling (C. Hidalgo and E. Jaimovich), Cancer (A. Quest), Steroidogenesis (L. Devoto) and Cell Death (S. Lavandero, A. Stutzin). In addition to this group of principal investigators, the Center has three research associates (C. Hetz, L. Michea, and D. Mears).
 7. Alejandra Alvarez, Catholic University of Chile, Santiago, Chile.
http://www.bio.puc.cl/lafacultad/home.asp?id_content=371
8. Joaquin Castilla, Script Florida, USA.
https://www.scripps.edu/research/faculty.php?rec_id=60171
9. Centro premio Nobel Mario Molina, Santiago, Chile
www.cmmolina.cl

 

MEDIA PRESS RELEASE
See comments about our research in:

http://www.redlideres.cl/1813/article-73910.html http://www.med.uchile.cl/noticias/2008/agosto/dr_hetz.html http://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_bio.cfm?ID=785 http://www.uchile.cl/uchile.portal?_nfpb=true&_pageLabel=not&url=47146 http://www.med.uchile.cl/noticias/2008/enero/dr_hetz.html http://www.universia.cl/html_estatico/portada/actualidad/noticia_actualidad/param/noticia/bcghjb.html http://www.med.uchile.cl/noticias/2007/octubre/dr_hetz.html
http://www.med.uchile.cl/boletin/2006/mayo/pag10.html
http://www.uchile.cl/uchile.portal?_nfpb=true&_pageLabel=not&url=11284
http://www.solociencia.com/biologia/05060205.htm
http://elaargentina.blogspot.com/
http://stke.sciencemag.org/cgi/content/abstract/emboj;22/20/5435
http://www.news-medical.net/?id=9409
http://stke.sciencemag.org/cgi/content/abstract/joces;115/23/4671
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2003/205/tw409
http://www.utmb.edu/impact/stories/2005/05APRIL18/prionarticle.htm
http://www.innovations-report.com/html/reports/life_sciences/report-43438.html
http://www.eurekalert.org/pub_releases/2005-04/uotm-spy041805.php http://www.med.uchile.cl/noticias/2008/abril/pdf/dr_hetz.pdf
http://www.universia.cl/portada/actualidad/noticia_actualidad.jsp?noticia=131553
http://www.uchile.cl/uchile.portal?_nfpb=true&_pageLabel=not&url=46100
http://icbm.cl/B7t.htm
http://www.chile.com/tpl/articulo/detalle/ver.tpl?cod_articulo=100536
http://www.f1000biology.com.ezp1.harvard.edu/search/results.asp?terms=
hetz&drpPhrase1=and&type=f1000_advanced_results&drpArticleType=&Search.x=10